Tumor Type: Rectal
Cancer
IRB Approval: 11/11/2008
RTOG 0822: A Phase II Evaluation of Preoperative Chemoradiotherapy
Utilizing Intensity Modulated Radiation Therapy (IMRT) in Combination
with Capecitabine and Oxaliplatin for Patients with Locally Advanced
Rectal Cancer
The primary objective of this study is to determine whether the
incidence of acute (preoperative) grade 2-5 gastrointestinal toxicity
associated with preoperative chemotherapy is reduced by inverse-planned
IMRT-based radiation treatment when compared to conventionally
delivered radiation treatment.
| Inclusion Criteria: |
Adenocarcinoma of the rectum up to 12 cm from the anal verge
Stage:
Any T3 or 4, N0 - 2, M0 |
| Exclusion Criteria: |
Prior invasive cancer < 3 years ago
MI
within last 6 months
Seizure
disorder |
| Treatment: |
Pre-operative IMRT in 28 Fractions + Capecitabine & Oxaliplatin
Surgery
Post-operative
chemotherapy: FOLFOX |
| Principle Investigator: |
Bong Chang, MD
Radiation
Oncology
Community
Medical Center
99
Route 37 West
Toms
River, New Jersey 08755
(732)
557-8148 |
| Study Site Coordinator: |
Debbie Moriarty, RN, MSN, OCN
Community
Medical Center
99
Route 37 West
Toms
River, New Jersey 08755
(732)557-8294 |
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