Newsletters

Healthy Child Spring/Summer 2005

Depression And Anxiety In Children And Adolescents: When To Consider Treatment

MARK P. FABER, M.D.
CHILD AND ADOLESCENT PSYCHIATRIST
DIRECTOR OF THE DIVISION OF PEDIATRIC PSYCHIATRY, SBMC

Childhood and adolescence should be a time of growth, carefree fun and learning within a kind, nurturing environment. As parents, we know just how quickly the years pass and respect the impact of our childhood years later in life. Depression and anxiety, however, may take their toll and prevent children from enjoying their friends, families, school or after-school activities.

Causes of Depression and Anxiety

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Types of Depression

  • Adjustment Disorder - following stress, the child feels sad or irritable but this generally passes over a period of time.
  • Dysthymia - generally a “blah” mood for most days over the past year although appetite and sleep may not be affected.
  • Major Depression - “clinical depression” lasting 2 or more weeks. The depressed or irritable mood impairs functioning, with sleep and appetite increased or decreased. The child has a decrease in energy, interest, and concentration along with decreased involvement in social or other activities. He or she may feel hopeless, helpless, and may feel like dying.
  • Bipolar Disorder, Depressed Type - Symptoms similar to major depression but also a history of euphoria, decreased need for sleep, racing thoughts, rapid speech, and sudden shifts in mood. One in five adolescents with major depression may
 
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Family history and genetics are real factors. In fact at the National Institute of Mental Health, researchers are using blood tests/DNA samples to identify who may develop clinical depression when under stress and which medication may be helpful. Brain biology plays a role with a decrease in neurotransmitters. Current and major past stressors also contribute.

Evaluation of Depression

It is very important to first rule out other medical factors which may contribute to or cause depressive symptoms. Lab workincluding thyroid testing, blood count, and electrolytes/liver enzymes may be done. Hypothyroidism and anemia may look like depression. Also evaluating sleep for excessive snoring, decreased breathing or leg movements in sleep may indicate sleep apnea or periodic limb movements in sleep. A careful history and clinical interview then may lead to a diagnosis of depression.

Treatment of Depression

For an adjustment disorder with depressed mood, a supportive family, friends and possibly brief counseling are usually effective. For dysthymia or major depression, a combination of medication combined with cognitive behavioral therapy is often the most successful treatment.

Medication Treatment of Depression

In children and adolescents (age 7 and above), only Prozac is FDA approved for treating depression, However there are studies to support the value of Zoloft and Celexa as well. Often a child will respond to a medication which has helped another family member if there is a family history of depression. Paxil and Effexor are not currently recommended for pediatric patients. Serotonin Reuptake Inhibitors (SSRI's) such as Prozac may cause headache, stomach upset, and decreased sleep.

The Antidepressant Controversy

Recently in the media there have been concerns that antidepressants may cause suicidal behavior in children and adolescents. The FDA has instructed drug companies to place a “black box” warning on allantidepressants because studies indicate a possible increase in suicidal thinking. The risk of such thinking may be seen as medication is started or increased.

Antidepressants however are effective and actually treat major depression more effectively than psychotherapy alone (TADS Study - Treatment of Adolescents with Depression). The key is gradual dosing and close follow up to minimize any risk. An increase in restlessness or irritability with medication use may be an important factor requiring a decrease or change of medication.

Types of Anxiety

  • Separation Anxiety: Intense fear, tearfulness when leaving home for school. Often the child will spend time in the nurse's office complaining of headaches or stomach upset without any obvious medical reason.
  • Panic Disorder: Discrete “out of the blue” anxiety attacks. The child may experience palpitations, shortness of breath and feel not in control. This is followed by worries about anxiety attacks (anticipatory anxiety) and avoidance of places where the child feels they will have a panic attack (phobic avoidance).
  • Obsessive Compulsive Disorder (OCD): Intrusive thoughts which may be combined with rituals. For example, fear of contamination /hand washing; fear of a burglar in the home/ checking locks; use of “magic number” /counting and recounting.
  • Social Anxiety Disorder: Anxiety attacks in social or performance situations. The child may avoid raising his or her hand in class or avoid class presentations. The adolescent may be very concerned about how they look, act, or sound and avoid parties or other social interaction.
  • Generalized Anxiety Disorder (GAD): Excessive worry about the day to day things and feeling very much “on edge”
  • Post Traumatic Stress Disorder (PTSD): After a terribly stressful event (accident, injury, etc.) nightmares, daytime intrusive memories,and “hypersensitivity” to situations resembling the traumatic event.

Evaluation of Anxiety

As with depression, it is important to rule out other factors which appear like anxiety. For example, excessive caffeine use may contribute to anxiety. Also an overactive thyroid may be ruled out with lab work. Finally, 50 percent of those with depression also experience significant anxiety. When the depression is treated, the anxiety also decreases.

Treatment of Anxiety with Psychotherapy

Cognitive Behavioral Therapy is very helpful. The “cognitive” part of treatment includes identifying exaggerated thoughts or worries, then challenging them with reasonable alternative thoughts. The “behavioral” part of treatment includes practicing diaphragmatic breathing (in through the nose, slowly out through the mouth) daily for 5-10 minutes. The breathing can gradually be combined with the stressful situation to help "desensitize" the child to this stressor. This therapy can be modified for the various anxiety disorders.

Medication Treatment of Anxiety

Zoloft and Luvox are FDA approved for treating OCD in children and adolescents (Zoloft: age 6 and above, Luvox: age 8 and above). Other SSRI's (except Paxil) may also be considered. These medications, in combination with psychotherapy may be effective in the various anxiety disorders beyond OCD. The key remains careful assessment and close follow up to assure the safe use if these medications.

Conclusion

Depression and anxiety may often be seen together in children. This may lead to difficulties functioning at home, in school, and socially if not treated. These conditions tend to run in families and may also be affected by stress. With careful evaluation and an effective plan of treatment, children may show a full improvement and enjoy their lives. Despite the recent controversy regarding antidepressants, these should be considered for major depression and severe anxiety with great care.

For an appointment with the Division of Pediatric Psychiatry, please call (973) 322-7600.

Prior to her appointment at Saint Barnabas, Dr. Friedman, board-certified in pediatrics, pediatric cardiology and pediatric critical care medicine, was Acting Chairman of Pediatrics and Director of Pediatric Cardiology at St. Luke's-Roosevelt Hospital Center in New York. She received her medical degree from the University of Chicago Pritzker School of Medicine and completed her internship and residency at Albert Einstein College of Medicine in the Bronx.

She has completed a Fellowship in Pediatric Cardiology at New York University Medical School. In addition, she had written more than 100 publications, abstracts, and book chapters. Currently, she is an investigator in a five year grant for $1.9 million which is studying the effects of Dexamethasone in Neonatal Lupus Congenital Heart Block.

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